该片围绕活泼可爱的螺丝钉展开故事。
《瑞克和莫蒂》第六季，北京时间9月5日开播。
在这部寓教于乐的成人喜剧动画中，勇敢的动物学家与活泼的侄子和焦虑的助手一边探索世界，一边拯救野兽。
Mermaid Man and Barnacle Boy decide to have lunch at the Krusty Krab. Learning this, Spongebob becomes overexcited and runs for an autograph, prompting the heroes to flee in fear and in the process, Mermaid Man drops his utility belt, which includes many features including a shrinking button, which Spongebob inadvertantly uses to shrink everyone in Bikini Bottom./Spongebob is in the process of failing his driving exam (yet again), and while they plunge off an unfinished bridge, Mrs. Puff imagines many outcomes of the event, one of which is going to jail.
本片剧情接续原本电影，叙述在史迪奇这“626号实验品”之前，强霸博士已有好几百个失败实验产物，如今强霸居然把这些实验产物全都偷偷走私到地球。心怀不轨的越狱者仓鼠飞轮和被开除而怀恨在心的刚图舰长联手，绑架了强霸博士，并且要去寻回之前的625个实验品，再次创造出全新的小魔星?这些希奇古怪的星际宝贝实验品包括有能发出强力电波的第221号实验品、懒惰却能做出美味三明治的第625号实验品等等。 如今，夏威夷七岁小女孩Lilo（莉萝）和星际宝贝Stitch（史迪奇）要协助星际联盟，在夏威夷群岛做地毯式搜索，抢在坏蛋之前找到625个实验品，并且还要帮这些星际宝贝都找到各自温暖的家！
